Bone Abstracts

Objective: GH through IGF1 plays an important role in both bone growth and mineralization. This cross-sectional study was carried out to evaluate the relationship between serum IGF1 concentrations and dual energy X-ray (DXA) measured total body less head (TB) bone area (BA), lean body mass (LBM) and bone mineral content (BMC).Methods: One hundred and nineteen children (B=70, age =7.3–15.6 years) were studied for their anthropometric paramet...

Objectives: High prevalence (20%) of adolescent pregnancy (AP) (1) is observed in India. Reports suggest that pregnancy during adolescence may have deleterious effects on peak bone mass (2). Few reports have described the long-term effects of history of AP on bone. The objective of this study was to compare bone density and geometry of premenopausal women having delivered first child during adolescence (before age of 19 years) or after 19 years.Methods: ...

Objectives: Patients with beta Thalassemia have been reported to have low bone mass; poorly chelated patients are likely to be at an even higher risk. Pubertal delay, hypogonadism, and reduced physical activity and sunlight exposure are likely to be additional contributors to poor bone health and increased fracture risk. The objective of our study was to assess the prevalence of fractures in Indian underprivileged, poorly chelated thalassaemic children.M...

Objectives: Beta thalassemia major (BTM) is characterized by anemia and iron overload, especially in children with inadequate chelation therapy. Dual energy x-ray absorptiometry software (DXA) may misanalyse bone measurements due to iron overload/deposition in organs such as the liver. Our objective was to study difference between the anterio-posterior spine measurements of bone mineral content (BMC), area (BA) and density (BMD) in non-chelated beta thalassaemia children with ...

Objectives: Association of grip strength (GS) with anthropometric parameters has been reported. Our objective was to assess grip strength in 6 to 18-year-old healthy Indian children (urban and rural) and study the association of GS with body composition.Methods: This was a part of a multicenter, cross-sectional, observational school-based study; multi-stage stratified random sampling was carried out and children (n=1980) from various urban (...

Objective: Children in rural areas have inadequate nutritional intake, hence their muscle function may be compromised. The objective of this study was to study the determinants of muscle function in rural Indian school going children.Methods: We cross sectionally studied 232 prepubertal school going children (106 girls) aged 6–11 years, from 2 different villages in rural area around Pune city in July 2018. Height, weight, body composition (bioelectr...

Objective: Type 1 diabetes (T1D) in one of the commonest chronic childhood disorders; poor muscle function and sarcopenia has been reported among T1D in adults. Reports on the impairment of muscle function are scarce in children. Our objective was to assess muscle mass and function in children with diabetes and study association of muscle mass and function with control of blood glucose (as measured by HbA1C) and disease duration.Methodology: This was a c...

Objective: Using DXA, we have previously reported that children with type 1 diabetes (T1D) had short and thin bones (Bone, 2015). Calcium supplementation promotes bone mass accrual with sustained benefit observed using milk/milk-based calcium but not calcium salts. To investigate effect of 1-year supplementation with milk vs pharmacological calcium salt on bone mineral density (BMD) and geometryin Indian underprivileged children with T1D. Both groups received vitamin D supplem...

Objectives: Low bone mineral density has been reported in children with beta thalassemia major, they also have increased propensity to fracture. We have studied DXA and pQCT variables in poorly chelated 3 to 18 year old thalassaemic patients and their relationship with fractures in this population.Methods: We studied 167, 3 to 18 year old children (Girls 72) with beta thalassemia major. Bone measurements were performed by GE iDXA (Lumbar Spine, Total bod...

Objective: Bone adapts to mechanical stimuli by increasing its mass and changing geometry; muscles are the stimulators for this change as they induce forces through contractions. Thus, bone strength is driven by muscle function. Research has shown that muscle mass and muscle function may not be proportional and hence analysing muscle function becomes of crucial importance. Here we propose to establish gender specific paediatric reference data for muscle function parameters ass...